Publications

BIOLOGY

Cancer, DNA Damage and Stress Response Networks

Bandyopadhyay S, Mehta M, Kuo D, Sung MK, Chuang R, Jaehnig EJ, Bodenmiller D, Licon K, Copeland W, Shales M, Fiedler D, Dutkowski J, Guenole A, van Attikum H, Shokat KM, Kolodner RD, Huh WK, Aebersold R, Keogh MC, Krogan NJ, Ideker T. Rewiring of genetic networks in response to DNA damage. Science 330:1385-1389 (2010) [Get PDF][Suppl Docs][PubMed link]
Kelley, R., Ideker, T. Genome-wide fitness and expression profiling implicate Mga2 in adaptation to hydrogen peroxide. PLoS Genetics 5(5):e1000488 (2009) [Get PDF][Pubmed link]
Chuang, HY, Lee, E, Liu, YT, Lee, D, and Ideker, T. Network-based classification of breast cancer metastasis.MolSyst Biol. 3:140 (2007). [Get PDF] [Online link]
Workman, CT., Mak, HC.,McCuine, S., Tagne, JB., Agarwal, M., Ozier, O., Begley, TJ., Samson, LD., Ideker, T. A Systems Approach to Mapping DNA Damage Response Pathways.Science. 312 (5776):1054-1059 (2006) [Get PDF][Supp. Info.] [PubMed link]
Haugen, A. C., Kelley, R. M., Collins, J. B., Tucker, C. J. Deng, C. D., Afshari, C. A., Brown, J. M., Ideker, T., Van Houten, B. Integrating phenotypic and expression profiles to map arsenic-response networks. Genome Biol. 5(12):R95. (2004). [Get PDF] [PubMed link]
Begley, T. J., Rosenbach, A. S., Ideker, T., Samson, L. D. Hot spots for modulating toxicity identified by genomic phenotyping and localization mapping. Molecular Cell16(1): 117-25 (2004).[Get PDF] [PubMed link]
Young ET, Dombek KM, Tachibana C, Ideker T. Multiple pathways are co-regulated by the protein kinase Snf1 and the transcription factors Adr1 and Cat8. J Biol. Chem., April 3 (2003). [Get PDF][PubMed link]
Begley, T., Rosenbach, A., Ideker, T., and Samson, L. Damage recovery pathways in Saccharomyces cerevisiae revealed by genomic phenotyping and interactome mapping.Molecular Cancer Research1: 103-112 (2002). [Get PDF][PubMed link]

Transcriptional Networks Driving Development of Tissues

Ravasi, T., Cannistraci, C.V., Katayama, S., Bajic, V.B., Tan, K., Akalin, A., Schmeier, S., Kanamori-Katayama, M., Bertin, N., Carninci, P., Daub, C.O., Forrest, A.R.R., Gough, J., Grimmond, S., Han, J., Hashimoto, T., Hide, W., Hofmann, O., Kaur, M., Kawaji, H., Kubosaki, A., Lassmann, T., van Nimwegen, E., MacPherson, C.R., Ogawa, C., Radovanovic, A., Schwartz, A., Teasdale, R.D., Tegnér, J., Lenhard, B., Teichmann, S.A., Hume, D.A., Ideker, T. An atlas of combinatorial transcriptional regulation in mouse and man.Cell 140(5):744-752 (2010)[Get PDF][Pubmed link]
Lin YC, Jhunjhunwala S, Benner C, Heinz S, Welinder E, Mansson R, Sigvardsson M, Hagman J, Espinoza CA, Dutkowski J, Ideker T, Glass CK, Murre C. A global network of transcription factors, involving E2A, EBF1 and Foxo1, that orchestrates B cell fate. Nature Immunology 11(7):635-643 (2010) [Get PDF] [PubMed link]

Host-Pathogen Interactions in Infectious Disease

Konig, R., Stertz, S., Zhou, Y., Inoue, A., Hoffmann, H.H., Bhattacharyay, S., Alamares, J., Tscherne, D.M., Ortigoza, M.B., Liang, Y., Gao, Q., Andrews, S.E., Bandyopadhyay, S., De Jesus, P., Tu, B., Pache, L., Shih, C., Orth, A., Bonamy, G., Miraglia, L., Ideker, T., Garcia-Sastre, A., Young, J.A.T., Palese, P., Shaw, M.L., Chanda, S.K. Human Host Factors Required for Influenza Virus Replication. Nature, 463:813-817 (2010) [Get PDF][Pubmed link]
Gersten, M., Alirezaei, M., Marcondes, M.C., Flynn, C., Ravasi, T., Ideker, T., Fox, H.S. An integrated systems analysis implicates EGR1 downregulation in SIVE-induced neural dysfunction. Journal of Neuroscience 29(40):12467-76 (2009) [Get PDF][Pubmed link]
Bushman, F.D., Malani, N., Fernandes, J., D'Orso, I., Cagney, G., Diamond, T.L., Zhou, H., Hazuda, D.J., Espeseth, A.S., Konig, R., Bandyopadhyay, S., Ideker, T., Goff, S.P., Krogan, N.J., Frankel, A.D., Young, J.A., Chanda, S.K. Host cell factors in HIV replication: meta-analysis of genome-wide studies. PLoSPathog 5(5):e1000437 (2009). [Get PDF][Pubmed link]
Fossum, E., Friedel, C.C., Rajagopala, S.V., Titz, R., Baiker, A., Schmidt, T., Kraus, T., Stellberger, T., Rutenberg, C., Suthram, S., Bandyopadhyay, S., Rose, D., von Brunn, A., Uhlmann, M., Zeretzke, C., Dong, Y.A., Boulet, H., Koegl, M., Bailer, S.M., Koszinowski, U., Ideker, T., Uetz, P., Zimmer, R., Haas, J. Evolutionarily conserved herpesviral protein interaction networks. PLoS Pathogens 5(9):e1000570 (2009) [Get PDF][Pubmed link]
Konig, R., Zhou, Y., Elleder, D., Diamond, T.L., Bonamy, G.M., Irelan, J.T., Chiang, C.Y., Tu, B.P., De Jesus, P.D., Lilley, C.E., Seidel, S., Opaluch, A.M., Caldwell, J.S., Weitzman, M.D., Kuhen, K.L., Bandyopadhyay, S., Ideker, T., Orth, A.P., Miraglia, L.J., Bushman, F.D., Young, J.A., Chanda, S.K. Global analysis of host-pathogen interactions that regulate early-stage HIV-1 replication. Cell 135(1):49-60 (2008). [Get PDF][Pubmed link]
Suthram, S., Sittler, T., and Ideker, T. The Plasmodium protein network diverges from those of other eukaryotes. Nature438(7064):108-12 (2005). [Get PDF] [Supp. Info.] [PubMed link]

Understanding transcriptional and epigenetic machinery

vanSteensel, B., Braunschweig, U., Filion, G.J., Chen, M., van Bemmel, J.G., Ideker, T. Bayesian network analysis of targeting interactions in chromatin. Genome Research, 20(2):190-200 (2010) [Get PDF][Pubmed link]
Mak, H.C., Pillus, L., Ideker, T. Dynamic reprogramming of transcription factors to and from the subtelomere. Genome Research 19(6):1014-25 (2009). [Get PDF][Pubmed link]
Tan K, Shlomi T, Feizi H, Ideker T, Sharan R. Transcriptional regulation of protein complexes within and across species. ProcNatlAcadSci USA. Jan 16 (2007). [Get PDF] [PubMed link]
Workman, CT., Mak, HC.,McCuine, S., Tagne, JB., Agarwal, M., Ozier, O., Begley, TJ., Samson, LD., Ideker, T. A Systems Approach to Mapping DNA Damage Response Pathways.Science. 312 (5776):1054-1059 (2006) [Get PDF][Supp. Info.] [PubMed link]
Beyer, A., Workman, CT., Hollunder, J., Radke, D., Möller, U., Wilhelm, T., Ideker, T. Integrated Assessment and Prediction of Transcription Factor Binding.ProcNatlAcadSci .103(25):9464-9 (2006). [Get PDF] [PubMed link]
Yeang, C.H., Mak, H.C., McCuine, S., Workman, C., Jaakkola, T., and Ideker, T. Validation and refinement of gene regulatory pathways on a network of physical interactions.Genome Biology6(7): R62 (2005). [Get PDF][PubMed link] [Supp. Info.]
Young ET, Dombek KM, Tachibana C, Ideker T. Multiple pathways are co-regulated by the protein kinase Snf1 and the transcription factors Adr1 and Cat8. J Biol. Chem., April 3 (2003). [Get PDF][PubMed link]
Ideker, T., Thorsson, V., Ranish, J. A., Christmas, R., Buhler, J., Eng, J. K., Bumgarner, R., Goodlett, D. R., Aebersold, R., and Hood, L. Integrated Genomic and Proteomic Analyses of a Systematically Perturbed Metabolic Network. Science, 292: 929-934 (2001). [Get PDF][Companion Website][Raw Data][PubMed link]

Evolution of Networks

Kuo D, Licon K, Bandyopadhyay S, Chuang R, Luo C, Catalana J, Ravasi T, Tan K, Ideker T. Coevolution within a transcriptional network by compensatory trans and cis mutations.Genome Research (2010) [Get PDF] [PubMed link]
Kuo D, Tan K, Zinman G, Ravasi T, Bar-Joseph Z, Ideker T. Evolutionary divergence in the fungal response to fluconazole revealed by soft clustering. Genome Biology 11(7):R77 (2010) [Get PDF] [PubMed link]
vanSteensel, B., Braunschweig, U., Filion, G.J., Chen, M., van Bemmel, J.G., Ideker, T. Bayesian network analysis of targeting interactions in chromatin. Genome Research, 20(2):190-200 (2010) [Get PDF][Pubmed link]
Fossum, E., Friedel, C.C., Rajagopala, S.V., Titz, R., Baiker, A., Schmidt, T., Kraus, T., Stellberger, T., Rutenberg, C., Suthram, S., Bandyopadhyay, S., Rose, D., von Brunn, A., Uhlmann, M., Zeretzke, C., Dong, Y.A., Boulet, H., Koegl, M., Bailer, S.M., Koszinowski, U., Ideker, T., Uetz, P., Zimmer, R., Haas, J. Evolutionarily conserved herpesviral protein interaction networks. PLoS Pathogens 5(9):e1000570 (2009) [Get PDF][Pubmed link]
Tan K, Feizi H, Luo C, Fan SH, Ravasi T, Ideker TG. A systems approach to delineate functions of paralogous transcription factors: role of the Yap family in the DNA damage response. ProcNatlAcad Sci. 105(8):2934-9 (2008). [Get PDF][Pubmed link]
Roguev, A., Bandyopadhyay, S., Zofall, M., Zhang, K., Fischer, T., Collins, S.R., Qu, H., Shales, M., Park, H.O., Hayles, J., Hoe, K.L., Kim, D.U., Ideker, T.*, Grewal, S.I.*, Weissman, J.S.*, Krogan, N.J.* Conservation and rewiring of functional modules revealed by an epistasis map in fission yeast. Science. 322:405-410 (2008). [Get PDF][Pubmed link] *Corresponding Authors
Tan K, Shlomi T, Feizi H, Ideker T, Sharan R. Transcriptional regulation of protein complexes within and across species. ProcNatlAcadSci USA. Jan 16 (2007). [Get PDF] [PubMed link]
Bandyopadhyay S, Sharan R, Ideker T. Cover Article: Systematic identification of functional orthologs based on protein network comparison. Genome Res. 16(3):428-35. (2006). [Get PDF] [PubMed link]
Suthram, S., Sittler, T., and Ideker, T. The Plasmodium protein network diverges from those of other eukaryotes. Nature438(7064):108-12 (2005). [Get PDF] [Supp. Info.] [PubMed link]
Sharan, R., Suthram, S., Kelley, R. M., Kuhn, T., McCuine, S., Uetz, P., Sittler, T., Karp, R. M., and Ideker, T. Cover Article: Conserved patterns of protein interaction in multiple species. ProcNatlAcadSci U S A. 8:102(6) 1974-79 (2005).[Get PDF][PubMed link] [Suppl. Website and Database of Conserved Pathways]

METHODS

Integration of Physical, Genetic, and Functional Interactions

Bandyopadhyay S, Chiang C, Srivastava J, Gersten M, White S, Bell R, Kurschner C, Martin CH, Sahasrabudhe S, Barber DL, Chanda SK, Ideker T. A human MAP kinase interactome.Nature Methods doi:10.1038/nmeth.1506 (2010) [Get PDF]
Hannum, G., Srivas, R., Guenole, A., van Attikum, H., Krogan, N.J., Karp, R.M., Ideker, T. Genome-wide association data reveal a global map of genetic interactions among protein complexes. PLoS Genetics 5(12):e1000782 (2009) [Get PDF][Pubmed link]
Schwartz, A.S., Yu, J., Gardenour, K.R., Finley, R.L. Jr., Ideker, T. Cost-effective strategies for completing the interactome. Nature Methods 6(1):55-61 (2009). [Get PDF][Pubmed link]
Bandyopadhyay S, Kelley R, Krogan NJ, Ideker T. Functional maps of protein complexes from quantitative genetic interaction data. PLoSCompu Biol. 4(4):e1000065 (2008). [Get PDF][Pubmed link]
Ourfali O, Shlomi T, Ideker T, Ruppin E, Sharan R. SPINE: a framework for signaling-regulatory pathway inference from cause-effect experiments. Bioinformatics. 23(13):i359-i366. Jul 1 (2007). [Get PDF][PubMed link]
Suthram S, Shlomi T, Ruppin E, Sharan R, Ideker T. A direct comparison of protein interaction confidence assignment schemes.BMC Bioinformatics. 7(1):360 (2006). [Get PDF][PubMed link]
Scott, J., Ideker, T., Karp, R., and Sharan, R.. Efficient algorithms for detecting protein signaling pathways in protein interaction networks. J Comput Biol. 13(2):133-44 (2006) [Get PDF][PubMed link]
Workman, CT., Mak, HC.,McCuine, S., Tagne, JB., Agarwal, M., Ozier, O., Begley, TJ., Samson, LD., Ideker, T. A Systems Approach to Mapping DNA Damage Response Pathways.Science. 312 (5776):1054-1059 (2006) [Get PDF][Supp. Info.] [PubMed link]
Kelley, R. and Ideker, T. Systematic interpretation of genetic interactions using protein networks. Nature Biotechnology23(5):561-566 (2005). [Get PDF][PubMed link]
Yeang, C.H., Mak, H.C., McCuine, S., Workman, C., Jaakkola, T., and Ideker, T. Validation and refinement of gene regulatory pathways on a network of physical interactions.Genome Biology6(7): R62 (2005). [Get PDF][PubMed link] [Supp. Info.]
Yeang CH, Ideker T, Jaakkola T. Physical network models. J Comput Biol. 11(2-3):243-62. (2004). [Get PDF] [PubMed link]
Ozier, O., Amin, N., and Ideker, T. Global architecture of genetic interactions on the protein interaction network. Nature Biotechnology21: 490-491 (2003). [Get PDF] [PubMed link]
Ideker, T., Ozier, O., Schwikowski, B., and Siegel, A. Discovering regulatory and signaling circuits in molecular interaction networks. Bioinformatics 18: S233 (2002). [Get PDF] [PubMed link]

Differential Networks, Network Dynamics, Network Comparison

Bandyopadhyay S, Mehta M, Kuo D, Sung MK, Chuang R, Jaehnig EJ, Bodenmiller D, Licon K, Copeland W, Shales M, Fiedler D, Dutkowski J, Guenole A, van Attikum H, Shokat KM, Kolodner RD, Huh WK, Aebersold R, Keogh MC, Krogan NJ, Ideker T. Rewiring of genetic networks in response to DNA damage. Science 330:1385-1389 (2010) [Get PDF][Suppl Docs][PubMed link]
Mak, H.C., Pillus, L., Ideker, T. Dynamic reprogramming of transcription factors to and from the subtelomere. Genome Research 19(6):1014-25 (2009). [Get PDF][Pubmed link]
Kuo D, Licon K, Bandyopadhyay S, Chuang R, Luo C, Catalana J, Ravasi T, Tan K, Ideker T. Coevolution within a transcriptional network by compensatory trans and cis mutations.Genome Research (2010) [Get PDF] [PubMed link]
Kalaev M, Smoot M, Ideker T, Sharan R. NetworkBLAST: comparative analysis of protein networks. Bioinformatics. 24(4):594-6 (2008). [Get PDF][Pubmed link]
Lee, K.Y., Chuang, H.Y., Beyer, A., Sung, M.K., Huh, W.K., Lee, B., Ideker, T. Protein networks markedly improve prediction of subcellular localization in multiple eukaryotic species. Nucleic Acids Research.doi: 10.1093/nar/gkn619 (2008). [Get PDF][Pubmed link]
Bandyopadhyay S, Sharan R, Ideker T. Cover Article: Systematic identification of functional orthologs based on protein network comparison. Genome Res. 16(3):428-35. (2006). [Get PDF] [PubMed link]
Workman, CT., Mak, HC.,McCuine, S., Tagne, JB., Agarwal, M., Ozier, O., Begley, TJ., Samson, LD., Ideker, T. A Systems Approach to Mapping DNA Damage Response Pathways.Science. 312 (5776):1054-1059 (2006) [Get PDF][Supp. Info.] [PubMed link]
Sharan, R., Suthram, S., Kelley, R. M., Kuhn, T., McCuine, S., Uetz, P., Sittler, T., Karp, R. M., and Ideker, T. Cover Article: Conserved patterns of protein interaction in multiple species. ProcNatlAcadSci U S A. 8:102(6) 1974-79 (2005).[Get PDF][PubMed link] [Suppl. Website and Database of Conserved Pathways]
Sharan R., Ideker, T., Kelley, B., Shamir, R., Karp, RM. Identification of protein complexes by comparative analysis of yeast and bacterial protein interaction data.J Comput Biol. 12(6):835-46. (2005). [Get PDF] [PubMed link]
Kelley, B. P., Yuan, B., Lewitter, F., Sharan, R. Stockwell, B. R., Ideker, T. PathBLAST: a tool for alignment of protein interaction networks. Nucleic Acids Research1;32: W83-8 (2004). [Get PDF][PubMed link]
Kelley, B. P., Sharan, R., Karp, R., Sittler, E. T., Root, D. E., Stockwell, B. R., and Ideker, T. Conserved pathways within bacteria and yeast as revealed by global protein network alignment. ProcNatlAcadSci U S A 100, 11394-9 (2003).[Get PDF][PathBLAST Website] [PubMed link]

Network-based Biomarkers of Development and Disease

Cannistraci CV, Ravasi T, Montevecchi FM, Ideker T, Alessio M. Nonlinear dimension reduction and clustering by Minimum Curvilinearity unfold neuropathic pain and tissue embryological classes. Bioinformatics 2 (18):i531-i539 (2010) [Get PDF] [PubMed link]
Ravasi, T., Cannistraci, C.V., Katayama, S., Bajic, V.B., Tan, K., Akalin, A., Schmeier, S., Kanamori-Katayama, M., Bertin, N., Carninci, P., Daub, C.O., Forrest, A.R.R., Gough, J., Grimmond, S., Han, J., Hashimoto, T., Hide, W., Hofmann, O., Kaur, M., Kawaji, H., Kubosaki, A., Lassmann, T., van Nimwegen, E., MacPherson, C.R., Ogawa, C., Radovanovic, A., Schwartz, A., Teasdale, R.D., Tegnér, J., Lenhard, B., Teichmann, S.A., Hume, D.A., Ideker, T. An atlas of combinatorial transcriptional regulation in mouse and man.Cell 140(5):744-752 (2010)[Get PDF][Pubmed link]
Lin YC, Jhunjhunwala S, Benner C, Heinz S, Welinder E, Mansson R, Sigvardsson M, Hagman J, Espinoza CA, Dutkowski J, Ideker T, Glass CK, Murre C. A global network of transcription factors, involving E2A, EBF1 and Foxo1, that orchestrates B cell fate. Nature Immunology 11(7):635-643 (2010) [Get PDF] [PubMed link]
Lee, E., Chuang, H.Y., Kim, J.W., Ideker, T., Lee, D. Inferring pathway activity toward precise disease classification.PLoSCompu Biol. 4(11): e1000217. doi: 10.1371/journal.pcbi.1000217 (2008). [Get PDF]
Chuang, HY, Lee, E, Liu, YT, Lee, D, and Ideker, T. Network-based classification of breast cancer metastasis.MolSyst Biol. 3:140 (2007). [Get PDF] [Online link]

Microarray Analysis and Processing

Kelley R, Feizi H, Ideker T. Correcting for gene-specific dye bias in DNA microarrays using the method of maximum likelihood. Bioinformatics. Epub ahead of print Jul 10 (2007).[Get PDF][PubMed link]
Hsiao, A., Ideker, T. Olesfky, J. and Subramaniam, S. VAMPIRE microarray suite: a web-based platform for the interpretation of gene expression data Nucleic Acids Research.33(Web Server issue):W627-32. (2005). [Get PDF][PubMed link]
Ideker, T., Thorsson, V., Siegel, A. and Hood, L. Testing for Differentially-Expressed Genes by Maximum-Likelihood Analysis of DNA Microarray Data. Journal of Computational Biology 7: 805-817 (2000). [Get PDF] [PubMed link]

Cytoscape and Computational Platforms

Smoot ME, Ono K, Ruscheinski J, Wang P-L, Ideker T. Cytoscape 2.8: New Features for Data Integration and Network Visualization. Bioinformaticsdoi: 10.1093/bioinformatics/btq675 (2010) [Get PDF]
Pentchev K, Ono K, Herwig R, Ideker T, Kamburov A. Evidence mining and novelty assessment of protein-protein interactions with the ConsensusPathDB plugin for Cytoscape. Bioinformatics (2010) [Get PDF] [PubMed link]
Mak HC, Daly M, Gruebel B, Ideker T. CellCircuits: a database of protein network models. Nucleic Acids Res. Jan (2007) ;35(Database issue):D538-45. Epub. Nov 29 (2006). [Get PDF][PubMed link]
Cline MS, Smoot M, Cerami E, Kuchinsky A, Landys N, Workman C, Christmas R, Avila-Campilo I, Creech M, Gross B, Hanspers K, Isserlin R, Kelley R, Killcoyne S, Lotia S, Maerel S, Morris J, Ono K, Pavlovic V, Pico AR, Vailaya A, Wang PL, Adler A, Conklin BR, Hood L, Kuiper M, Sander C, Schmulevich I, Schwikowski B, Warner GJ, Ideker T*, and Bader GB. (Ideker is corresponding author). Integration of Biological Networks and Gene Expression Data using Cytoscape.Nature Protocols, 2(10):2366-82 Oct 1 (2007). [Get PDF][Online link]
Shannon, P., Markiel, A., Ozier, O., Baliga, N. S., Wang, J. T., Ramage, D., Amin, D., Schwikowski, B., and Ideker, T. Cytoscape: A software environment for integrated models of biomolecular interaction networks. Genome Research13, 2498-504 (2003).[Get PDF] [Cytoscape Website][PubMed link]