NEWS

2025

Witthaya Prasongsin—Getty Images

The U.S. just bet $1 billion that AI supercomputers can turn most cancers from ‘death sentences’ to ‘manageable conditions’ within 8 years

Fortune, Eva Roytburg (October 28, 2025) [View PDF]

“Can we make a massive dent in cancer with AI and big data in the next eight years? Absolutely,” scientist Trey Ideker said. “Is AI alone going to solve cancer? No.”
Ludmil Alexandrov (L) and Trey Ideker (R) are both on teams selected for the shortlist of Cancer Grand Challenges. (Photo credit: UCSD Health Sciences)

UC San Diego Researchers Shortlisted for International Cancer Competition
UC San Diego Today, Miles Martin (Sept 29, 2025) [PDF]

Twelve teams reached the Cancer Grand Challenges finals, including two with UC San Diego scientists. Dr. Ideker’s Team ‘Biologia Ex Machina’ is developing the next generation of AI-powered co-scientists to revolutionize cancer research.  

Human cell illustration. (Image Credit: Corona Borealis Studio/Shutterstock)

This Detailed Map of a Human Cell Could Help Us Understand How Cancer Develops
Discover Magazine, Cody Cottier (May 29, 2025) [PDF

Mapping a human cell gives researchers a view of subcellular architecture and sheds light on how cancer develops

Photo Credit: UC San Diego Health Sciences/University Communications

“Digital Tumors” for Precision Oncology: UC San Diego Receives Award from ARPA-H
UC San Diego Today, Miles Martin (May 22, 2025) [PDF]

Researchers at UC San Diego, led by Professor Trey Ideker, are included in a $142 million initiative from ARPA-H with the goal of creating adaptive and personalized cancer treatments. As part of the new project, Ideker will lead a team developing “digital tumors” to help match patients with the right treatment and predict the evolution of their disease. 

Photo Credit: UC San Diego Health Sciences/University Communications

UCSD team is part of cutting-edge, nationwide cancer program
The San Diego Union-Tribune, Paul Sisson (May 23, 2025) [PDF]

Grants will fund use of artificial intelligence to predict cancer evolution during treatment and better match treatments to disease

ARPA-H ADAPT Program

ARPA-H pioneers game-changing cancer care designed to adapt throughout treatment
ARPA-H News & Events (May 20, 2025) [PDF]

Selected performer teams will use predictive models to match treatments with changing tumor biology and prevent disease progression

Mutations traced to disrupted protein complexes, not just single faulty parts.

Protein Map Illuminates Hidden Drivers of Childhood Cancer
AACR Cancer Discovery News, Elie Dolgin (April 25, 2025) [PDF]

A high-resolution map of how protein organization inside the cell provides a platform for interrogating the way cancer mutations disrupt entire protein assemblies—not just individual genes. By combining spatial proteomics with pediatric tumor genome data, researchers uncovered 102 previously overlooked cancer drivers, highlighting the power of structural context in interpreting cancer genomes and identifying new therapeutic targets.

Photo Credit: Human Protein Atlas

A Comprehensive Map of the Human Cell
UC San Diego Today, Susanne Clara Bard (April 9, 2025) [PDF]

UC San Diego and Stanford University researchers have created a comprehensive map of the human U2OS cell. The map revealed previously unknown functions of proteins including C18orf21 (pictured).

Image credit: SynBioBeta using DALL-E

Epigenetic Clocks May Only Be Scratching the Surface of Aging
SynBioBeta (Jan 21, 2025) [PDF]

UC San Diego researchers uncover a pivotal link between genetic mutations and epigenetic changes, reshaping our understanding of aging

Photo: Zane Koch and Trey Ideker

What makes the biological clock tick? La Jolla scientists link two theories on aging
The San Diego Union-Tribune, La Jolla Light, Ashley Mackin Solomon (Jan 27, 2025) [PDF

UCSD researchers work to pave the way for new therapies to slow or reverse the process. Zane Koch and Trey Ideker are authors of a study out of the UC San Diego School of Medicine on aging. 

Is aging caused by gene expression or mutations? The answer is key to treatment
KPBS Public Media, Thomas Fudge (Jan 27, 2025) [YouTube][PDF]

What do your genes have to do with growing old? Quite a lot. But is it due to the actual DNA, or the way those genes are expressed? KPBS sci-tech reporter Thomas Fudge has more on new research that raises a question that’s key to treating age-related conditions.

Image: Dmytriy (stock.adobe.com)

Is anti-aging science misguided? ‘Reversing’ your biological clock may be out of reach
StudyFinds, Steve Fink (Jan 24, 2025) [PDF]

Findings challenge current anti-aging research focused solely on reversing epigenetic changes, as these changes may be symptoms rather than root causes of aging – making the development of anti-aging treatments more complex than previously thought.

New Study Links Epigenetic Changes to Genetic Mutations. There may be negative implications for epigenetic therapies
Lifespan.io, Arkadi Mazin (Jan 21, 2025) [PDF]

A new paper published in Nature Aging suggests that somatic mutations cause significant remodeling of the epigenetic landscape. The findings might be relevant to future anti-aging interventions.

Image credit: UC San Diego Health Sciences/Adobe Firefly

Why Our Biological Clock Ticks: Research Reconciles Major Theories of Aging.
UC San Diego Today, Miles Martin (Jan 21, 2025) [PDF]

Two major theories of aging both involve DNA, but in very different ways. Researchers at UC San Diego have revealed that these theories may not be so different after all.

Inside the Lab: Researcher Spotlight with Dr. Trey Ideker
UC San Diego, Moores Cancer Center. Izzy Ancharski (Jan 7, 2025) [Vimeo, 15mins

Trey Ideker, PhD, is a 21-year Professor of Medicine, Bioengineering and Computer Science, and former Chief of Genetics, at the University of California San Diego (UCSD). Additionally, he is Director or Co-Director of the Bridge2AI Functional Genomics Data Generation Program, the Cancer Cell Map Initiative, the National Resource for Network Biology, and the UCSD Graduate Program in Bioinformatics and Systems Biology, all NIH-funded efforts. Ideker’s research laboratory has led seminal studies establishing the theory and practice of systems biology, including systematic techniques for elucidating human cell architecture and its molecular networks.

View the complete Researcher Spotlight series HERE 

2024

Dr. Ideker has been selected as a Clarivate Highly Cited Researcher, continuing his ongoing nomination since 2019. This highly anticipated annual list identifies researchers who demonstrated significant influence in their chosen field or fields through the publication of multiple highly cited papers during the last decade.  (Published December 2024)
View the complete list of 
2023 Highly Cited Researchers HERE

Image credit: UC San Diego

All In. Transforming cancer treatment with artificial intelligence (pgs 12-17)
Delivering Discoveries. Moores Cancer Center Annual Impact Report FY 2024 

UC San Diego Moores Cancer Center is committed to supporting patients at every step of their cancer journey. Through innovative research and compassionate patient care, we strive to change the landscape of cancer prevention, detection, and care in San Diego and beyond. Our inaugural annual report features inspiring patient stories, research breakthroughs, community partnerships and more.

 Read Here

Image credit: UC San Diego Health Sciences, generated with Adobe Firefly

How Artificial Intelligence Could Automate Genomics Research. UC San Diego Today, Miles Martin (Dec 2, 2024) [PDF]

Functional genomics seeks to identify what genes do and how they interact. Researchers at UC San Diego have demonstrated that large language models such as GPT-4 could make functional genomics research significantly faster and less laborious than current, non-AI approaches. 

See also: Medical Express

Photo credit: iStock/Lillia Bila

$12.7M Grant to Establish New Center to Investigate Genetic Basis of Autism and Schizophrenia
UC San Diego Today, Sara Bock (Oct 10, 2024)

Funded by a California Institute for Regenerative Medicine (CIRM) grant, researchers in the UC San Diego Verge Center aim to uncover the genetic mechanisms behind neuropsychiatric disorders. 

CBS8 News San Diego

UC San Diego School of Medicine uses AI to predict which drugs to use to treat cancer patients
CBS8 News San Diego, Abbie Black (Jan 18, 2024) [PDF] [YouTube]

The team published a study in Cancer Discovery that uses artificial intelligence to predict the best treatment for cancer patients.

Podcast: BBC Crowd Science

Why can’t my dog live as long as me? To live for days or for decades? We uncover how an animal’s lifespan is determined.

BBC World Service, CrowdScience (Nov 22, 2024)
[Podcast, 29 mins]

Photo credit: Erik Jepsen/UC San Diego

Simulated Chemistry: New AI Platform Designs Tomorrow’s Cancer Drugs
UC San Diego Today, Miles Martin (May 6, 2024) [PDF]

The new platform helped UC San Diego scientists synthesize 32 potential multi-target cancer drugs. Photo: Study co-author Katherine Licon, photographed here at the bench, is lab manager for the Ideker Lab at UC San Diego, which combines computational and traditional wet-lab techniques to answer fundamental questions about disease biology and discover new ways to enhance precision medicine. 

    Image credit: istock.com

    Infusion of Artificial Intelligence in Biology
    The Scientist, Meenakshi Prabhune (Feb 23, 2024) [PDF]

    With deep learning methods revolutionizing life sciences, researchers bet on de novo proteins and cell mapping models to deliver customized precision medicines. As the AI flood gates open, biology is experiencing a surge of new applications. From synthetic proteins to cell mapping, researchers are using AI to improve precision medicines. 

    Machine Learning Models Help Predict Medication Responses
    NIH, National Cancer Institute, Center for Biomedical Informatics and Information Technology (CBIIT) (Feb 5, 2024) [PDF]

    Image credit: Allen Chen/UCSD Guardian, using Dreamstudio

    Scientists use AI to predict when cancer cells will resist chemotherapy
    Interesting Engineering, Sejal Sharma (Jan 18, 2024)

    Photo by Steve Johnson on Unsplash

    AI points to better and new cancer treatments
    Innovators Magazine, Susan Robertson (Jan 18, 2024)

    Credit: BlackJack3D/Getty Images

    AI Uses Tumor Genetics for Prediction of Treatment Response
    Inside Precision Medicine (Jan 18, 2024)

    Photo credit: National Cancer Institute/Unsplash

    AI Harnesses Tumor Genetics to Predict Treatment Response. There are many paths to cancer resistance; AI can decode them all simultaneously.
    UC San Diego Today, Miles Martin (Jan 18, 2024) [PDF]

    Cervical cancer, shown here at the cellular level, frequently resists treatment. The researchers’ machine learning algorithm could help scientists better understand why this and other forms of cancer resist chemotherapy. 

    2023

    Forbes 30 Under 30, Class of 2023

    Congratulations to Dr. Yue Qin!

    Dr. Yue Qin has been selected to join the Forbes 30 Under 30, Class of 2023. Read more HERE and HERE. (2023 May 17)

    Dr. Yue Qin has been awarded the 2023 UC San Diego Chancellor’s Dissertation Medal for the Jacobs School of Engineering. (2023 May 10)

    Image provided by NIH Common Fund

    A New Map Reveals the Complicated World in Which Cells Seek to Repair Damaged DNA
    Scott LaFee, UC San Diego Today.  (2023 May 22) [PDF]

    Image: An artistic rendering of the concept of DNA damage and repair. Numerous diseases are linked to or caused by alterations that affect genomic integrity and the ability of cells to function and divide normally. A process called DNA damage response has evolved to repair errors and mutations. Researchers have produced a new map that more fully captures the complexity of that process.

    Image: UC San Diego Today

    Smartly Done. Artificial intelligence is on its way to transforming how we understand and treat disease. 
    UC San Diego Today, Nicole Mlynaryk (2023 May 18) [PDF]

    “The same way your Netflix algorithm predicts what movie you should watch tonight, our algorithms will predict what drug is best fit to treat your cancer”. – Trey Ideker

    Watch on YouTube

    Creating a Meaningful College Experience with Ximena Gonzalez
    University of California Television (UCTV). YouTube. (Jun 29, 2023)

    2022

    Lucila Ohno-Machado, MD, PhD, is the PI of the Bridge Center’s Administrative and Ethics cores. Trey Ideker, PhD, is the PI of a Data Generation Project called Cell Maps for AI.

    UC San Diego Joins NIH ‘Bridge to Artificial Intelligence’ Program
    UC San Diego Today, Nicole Mlynaryk (September 13, 2022) [PDF]

    The NIH Common Fund’s initiative will expand the use of artificial intelligence to solve pressing challenges in human health. Researchers at University of California San Diego School of Medicine have been selected to lead components of the National Institutes of Health (NIH) Common Fund’s Bridge to Artificial Intelligence (Bridge2AI) program. Over the next four years, Bridge2AI will award $130 million to accelerate the widespread use of AI in biomedical research and health care 

    Dr. Trey Ideker is honored to be included in the ISCB 2022 Class of Fellows. 

    The ISCB Fellows program was created to honor members who have distinguished themselves through outstanding contributions to the fields of computational biology and bioinformatics. Begun in 2009, 2022 marks the 13th anniversary of the program. ISCB will be honoring the 2022 Class of Fellows during the annual ISMB 2022 conference. (April 28, 2022) 

    How old is your dog in human years? New formula is more accurate than multiplying by 7. The Kelly Cutrara Show, Global News Radio 640 Toronto.  (4 Feb 2022)

    Radio interview with Trey Ideker & Kelly Cutrara

    Image courtesy of the Spanish National Cancer Research Center and Massachusetts General Hospital.

    Scientists develop novel tools to visualize DNA repair.  
    The Science Advisory Board, Monish Makena (4 Jan 2022) 

    Researchers can now visualize DNA repair in unprecedented detail using a new high-throughput microscopy technique in combination with machine learning. The methodology, published in Cell Reports on December 28, has led to the identification of new proteins involved in DNA repair.

    2021

    "From COVID to cancer, gene-mapping tool could 'revolutionize' treatment." San Francisco Chronicle (Oct 2021)
    "COVID-19: Scientists Identify Human Genes That Fight SARS-CoV-2 Infection." SciTech Daily (Apr 2021)
    "Uncovering Key Interactions Between Cancer-Driving Proteins." Technology Networks (Oct 2021)
    "In-Depth Cancer Protein Mapping Project Sheds Light on Disease Processes." Clinical Omics (Oct 2021)
    "Old Dogs, New Research and the Secrets of Aging." New York Times (Nov 9, 2020)

    2020

    "Quantitative Translation of Dog-to-Human Aging by Conserved Remodeling of the DNA Methylome." Wang, et al. Cell Systems. 2020
    DrugCell: New Experimental AI Platform Matches Tumor to Best Drug Combo. UC San Diego researchers use artificial intelligence to predict best approach to treating cancer(Oct 2020)

    2019

    "Cracking Open the Black Box of AI with Cell Biology" IEEE Spectrum. (Mar 13, 2018)

    2018

    San Diego Union Tribune interview with Dr. JP Shen. "Gene Editing Approach Uncovered Cervical Cancer’s Weak Spots" (March 22, 2017)

    2017

    2016

    "People Who Are HIV-Positive May Be Aging Faster Than Their Peers" NPR (April 26, 2016)

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