Ideker Lab

UC San Diego 
School of Medicine

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The long-term objective of the Ideker Lab is to create artificially intelligent, mechanistic models of cancer and neurodegenerative diseases for translation of patient data to precision diagnosis and treatment. We seek to advance this goal by addressing fundamental questions in the field: What are the genetic and molecular networks that promote disease, and how do we best chart these? How do we use knowledge of these networks in intelligent systems for predicting the effects of genotype?

Desmosome mutations impact the tumor microenvironment to promote melanoma proliferation

Maayan Baron, et al. Nature Genet. 2025

Multimodal cell maps as a foundation for structural and functional genomics

Leah Schaffer, et al. Nature 2025

Integrated multi-omic characterizations of the synapse reveal RNA processing factors and ubiquitin ligases associated with neurodevelopmental disorders

Yuan Mei, et al. Nature Genet. 2025

Somatic mutation as an explanation for epigenetic aging

Zane Koch, et al. Nature Aging 2025

The Hallmarks of Predictive Oncology

Akshat Singhal, et al. Cancer Discovery 2025

State of the interactomes: an evaluation of molecular networks for generating biological insights.

Sarah Wright, et al.  Mole Syst Biol. 2025

A multilineage screen identifies actionable synthetic lethal interactions in human cancers

Samson Fong, et al. Nature Genet. 2024

Putting proteins in context
Mengzhou Hu, et al. Cell Systems 2024

Prediction of immunotherapy response using mutations to cancer protein assemblies

JungHo Kong, et al. Sciences Advances 2024

Get to know the individuals behind the Ideker Lab. Discover available positions within our lab and explore career opportunities in bioinformatics, cancer cell research, and related disciplines at other organizations.

What the Ideker Lab is reading . . . The Network Biology journal club was established by the Ideker Lab in 2016 to review and evaluate scientific papers in the area of systems biology. All UCSD trainees and research scientists are welcome to attend these meetings, click link below to view upcoming meeting schedule and past papers.

    Join Our Team

    The Ideker Lab is recruiting exceptional bioinformatics graduate students, postdocs, and senior research scientists to work across multiple laboratory projects. Prior to submitting an inquiry on available positions, please click the link below to learn more about how to apply. 

    Research Centers & Affiliates​